This example came from healthy porcine aorta that was stained with Hematoxylin and Eosin (H&E). Using an area-based algorithm, we can quantitatively evaluate the sample for elastin percentage. Elastin is a critical component of the microstructure within large arteries such as the aorta. This type of quantitative analysis can be performed on various types of samples including synthetic vascular grafts (e.g. BARD Impra, Atrium, or GORE) or other biological conduits following explant (e.g. saphenous vein, internal mammary artery grafts). Numerous other medical device applications can leverage the area-based algorithms for quantitative analysis following histology or immunohistochemistry processing. For example, biocompatibility analysis, such as fibrous capsule presence, can benefit from whole-slide area based algorithm analysis.
