Measuring brown fat with digital pathology in histology sections

Brown fat measurement

We receive frequent requests for measuring brown fat. Below are some examples, with the same Flagship fat algorithm that was used previously for white fat and lung alveoli.

Area and perimeter histogram results on brown fat — Area and perimeter results per brown fat vacuole. Note that most of the vacuoles are around 500 um2.

Here is a different section showing fat vacuole measurement — Here is a much lighter tissue section, again showing the fat vacuole identification

Fat vacuoles are identified in a fatty liver section — Fat vacuole results from a fatty liver section

Fatty liver vacuoles are identified and statistics computed — A second fatty liver section

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Dependable clinical diagnostic testing to connect patients to individualized, immuno-oncology therapies.

Flagship carefully tracks our tissue to ensure we can analyze every assay and stay on schedule.

We are trying to bridge from the discovery stage to clinical development. Flagship's pathologists and scientists provide critical input and the company helps us organize and analyze an incredible amount of data. I highly recommend Flagship for its expertise and support for drug development projects.

During clinical trials, I interact with our manufacturing, legal, pre-clinical, and biomarker teams. Our Flagship project manager understands our tight timeline and ensures delivery of the data we need, when we need it.

We are pleased to partner with Flagship Biosciences to integrate their machine learning/AI tools to provide cancer marker detection.

Flagship’s image analysis experts are flexible and willing to work with us to develop projects that meet the changing needs of our clinical trials drug development.

Flagship has a high reputation as a supplier of advanced IHC services and their CAP-CLIA environment is a perfect complement to our own testing facilities.

The ease of leveraging Flagship’s powerful solution is yet another massive differentiator of the company. Clients need not have to change their existing workflows, investments in technology, or even the assays that they use.

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Brown fat measurement

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