Bridge scanning of implanted materials

We have a number of multi-modal whole slide scanning techniques that we call bridge scanning, where a number of fluorescent and brightfield scans are overlaid, either from a single slide or from multiple consecutive sections. In this example, we are using FACTS with other consecutive sections to identify biocompatible responses to implanted biopolymers. We can scan a slide in brightfield and then use bridge scanning in the same section to identify the biomaterial in fluorescence. The biomaterial region is then marked and the responses of different biocompatibility measurements (e.g. fibrous capsule, infiltrating immune cells, angiogenesis, etc.) can be measured as a distance from this material.

Fibrous capsule measurements of an implanted biomaterial using both fluorescence and brightfield scanning on the same slide
Bridge scanning involves the novel combination of brightfield and fluorescent scanning. In this implanted device application, an embedded biopolymer can be identified in a fluorescent scan on the same slide as a brightfield stain and overlaid in a number of ways in studying biocompatibility